Angela Denoke was born in Stade near Hamburg in Germany.  After completing her studies at the "Hochschule für Musik und Theater" in Hamburg, she joined the ensemble of the Theater Ulm followed by the Staatsoper Stuttgart. 

She is closely associated with the Opera National de Paris (Katya Kabanova, Cardillac, Der Rosenkavalier, Wozzeck, Parsifal, Fidelio, and The Makropulos Affair), the Vienna State Opera (Lady Macbeth of Mtsensk, Arabella, Salome, Die tote Stadt, Parsifal, Jenufa, Der Rosenkavalier, Lohengrin and Tannhäuser), the Deutsche Staatsoper Berlin (Tannhäuser, Fidelio, Pique Dame and Erwartung under Daniel Barenboim, Der Rosenkavalier and Tannhäuser under Philippe Jordan) and the Bayerische Staatsoper (Salome, Der Rosenkavalier and Wozzeck). For the Salzburg festivals she has sung Katya Kabanova, Die Tote Stadt, Wozzeck and Fidelio.  She has sung with the London Symphony Orchestra (Daniel Harding and Valery Gergiev) and the Berliner Philharmoniker (Sir Simon Rattle) and appears at the Royal Opera House, Metropolitan Opera New York, Netherlands Opera, Semperoper Dresden, Teatro Real Madrid, Gran Teatre del Liceu Barcelona and at the Paris Chatelet. She recently made a highly acclaimed debut at Teatro alla Scala in Milan in The Makropulos Affair.

Her future engagements include appearances with the Berliner Philharmoniker and Sir Simon Rattle. She returns to London (Salome), Munich (Parsifal and Jenufa), Vienna (Parsifal, Jenufa, Pique Dame), Berlin (Salome) and Paris (Katya Kabanova and Salome). 

Her recordings include Die tote Stadt, Die Walküre, Kátya Kabanová, Cardillac, Beethoven 9 (with Mikhail Pletnev for DG and Daniel Barenboim for Warner), Wozzeck (with Ingo Metzmacher for EMI) and Fidelio (with Sir Simon Rattle for EMI).

Her jazz and song programme “From Babelsberg to Beverly Hills” which is mainly devoted to the era of Marlene Dietrich and Zarah Leander tours to the Kurt Weill Festival in Dessau and to the opera houses of Munich, Madrid, Barcelona, Oviedo, Frankfurt, Paris and Milan.

She was voted Singer of the Year by Opernwelt in 1999 and in 2007 she received the Deutsche Theaterpreis Der Faust for her portrayal of Salome.  In February 2009 the Austrian Government awarded the title of Kammersängerin of the Wiener Staatsoper.